Home Blog Sample Report Get Early Access
DeepDNA› Genes
⚠ NOTICE

These pages are for educational purposes only. They are not medical advice or diagnostic tools. Genetic information should be interpreted by a qualified healthcare professional.

Gene Pages · Reference

Genes

Eleven genes · primary-source citations · interactive variant lookup

An evidence-first reference for the genes most commonly discussed in consumer DNA analysis. Each page covers what the gene does, the common variants, the clinical significance (with citations to ClinVar and primary literature), and how to look up your own genotype if you have raw data from 23andMe, AncestryDNA, MyHeritage, or VCF.

Reference — 11 genes

Start here.

MTHFR — folate metabolism and methylationC677T and A1298C: what the evidence actually supports for plasma homocysteine, folate, and clinical outcomes. COMT — dopamine, stress, and the warrior/worrier storyThe Val158Met (rs4680) variant and how it shifts prefrontal dopamine clearance. CYP2D6 — drug metabolism's most variable enzymeStar alleles, metabolizer phenotypes, and CPIC-guided dosing for codeine, tamoxifen, and antidepressants. CYP2C19 — the clopidogrel geneStar alleles *2, *3, *17 and CPIC dosing for clopidogrel, PPIs, and antidepressants. The pharmacogene your raw data reads best. CYP2C9 — the warfarin geneStar alleles *2, *3 and VKORC1: how genotype sets warfarin sensitivity, dose, and bleeding risk — plus phenytoin and NSAIDs. SLCO1B1 — statins and muscle painHow the rs4149056 variant raises statin levels and myopathy risk, and which statins are safer. One SNP, real clinical signal. G6PD — favism and drug-triggered hemolysisThe most common enzyme deficiency worldwide: Mediterranean and A− variants, fava beans, and drugs to avoid. UGT1A1 — Gilbert syndrome and bilirubinThe *28 promoter variant behind mild high bilirubin, plus its effect on irinotecan chemotherapy dosing. HFE — hemochromatosis and iron overloadC282Y and H63D, why most carriers never get sick, and the blood test that settles it. APOE — lipid transport and Alzheimer's riskThe ε2/ε3/ε4 alleles, defined by rs429358 and rs7412, and what each genotype means for lifetime risk. BRCA1 — hereditary breast and ovarian cancerWhy a consumer SNP test is not the right tool — and what the right tool looks like.

The catalogue grows gene by gene, prioritised by real search demand and by which variants consumer raw data can actually resolve. Next up are the pharmacogenes with CPIC guidance and the metabolic genes most often misread in consumer reports.